【問題】酶的功用

[豹紋守宮WG 10]

大家都知道,"酶"是生物體內的蛋白質性(大部份)的催化劑,它的作用是降低活化能障礙,使反應較易進行,

問題:

1.它如何降低活化能障礙???

2.輔因子(或輔酶)如何作用於酵素(是作用於活化位上嗎???)

3.有沒有人有辦法舉例並說明所謂的"多酵素複合體"

[訪客]

大家都知道,"酶"是生物體內的蛋白質性(大部份)的催化劑,它的作用是降低活化能障礙,使反應較易進行,

問題:

1.它如何降低活化能障礙???

2.輔因子(或輔酶)如何作用於酵素(是作用於活化位上嗎???)

1.催化劑能夠和反應物之一以較低的活化能結合，反應物-催化劑複合物可以以一樣比較低的活化能反應成產物，並且產物跟催化劑分離。這在化學課會教。

2.不是，輔酶是結合在酵素的另外一個地方，這個結合會造成酵素的構型改變，因而更容易和反應物作用。

[豹紋守宮WG 10]

1.所以"酵素"與化學中的催化劑作用方式一樣了嗎???

2.是結合在異相位上嗎?

[starjimmy 10]

But another thing... cofactor can be part of the catalytic complex...

Just give an example, if you go to NCBI and search for cytochrome P450, you can discover that it has a heme group, with Fe2+ in the middle of heme. Without that cofactor, the enzyme would never function. There are also ample examples in the CAC that shows this.

Also, it is important to recognize that enzyme itself is a kind of catalyst.

[豹紋守宮WG 10]

1.所以酵素是一種催化劑 只不過他同時是一種蛋白質

2.輔因子也有可能是使酵素開始作用的Key!!

p.s.My English is too poor to report you with English

[starjimmy 10]

enzyme is not necessarily a kind of protein.. think about the ribozyme

[Yu-Hsiang 10]

多酵素複合體是一長串的酵素　感覺有點像電子傳遞鏈那樣

第一個酵素的產物是第二個酵素的受質

第二個酵素的產物是第三個酵素的受質...等等這樣下去直至終產物生成為止

我在想這說不定跟細胞溝通扯的上關係

[david6602ok 10]

But another thing... cofactor can be part of the catalytic complex...Just give an example, if you go to NCBI and search for cytochrome P450, you can discover that it has a heme group, with Fe2+ in the middle of heme. Without that cofactor, the enzyme would never function. There are also examples in the CAC that shows this.Also, it is important to recognize that enzyme itself is a kind of catalyst.Enzyme is not necessarily a kind of protein.. think about the ribozyme

若翻譯不好請見諒：

但輔酶亦能夠作為催化的物質之一部分。例如你上NCBI網站，搜尋細胞色素P450，你能發現：它含有二價鐵在血基質中央的血基質團。沒有那輔酶，酶將無法作用；而CAC亦是個例子。此外，了解酶是一種催化物是件重要的事。酶不見得一定要是蛋白質，例如ribozyme（RNA作為酶）

[starjimmy 10]

There are also examples in the CAC that shows this.

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其實我原本要說的是在CAC(檸檬酸循環)當中也有許多例子說明這點